Early Detection Research Network

TRAF4

Aliases:
This biomarker is also known as:
  • tumor necrosis receptor-associated factor 4A,
  • cysteine-rich domain associated with RING and Traf domains protein 1,
  • MLN 62,
  • RING finger protein 83,
  • cysteine-rich domain associated with ring and TRAF domain,
  • metastatic lymph node gene 62 protein,
  • Cysteine-rich domain associated with RING and Traf domains protein 1,
  • MLN62,
  • malignant 62,
  • TRAF4,
  • RNF83,
  • CART1,
  • Metastatic lymph node gene 62 protein,
  • TNF receptor-associated factor 4,

Description…

TRAF4 is a member of the TNF receptor associated factor (TRAF) family. Members of the TRAF family are the major signal transducers for the TNF receptor (TNFR) superfamily and the interleukin-1 receptor/Toll-like receptor superfamily. TRAF4 is involved in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: TRAF4

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

The TRAF4 gene is amplified in breast carcinoma. TRAF4 is also involved in the regulation of the TGF-β pathway and in subsequent breast cancer pathogenesis.

Performance Comment

TRAF4 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.