TRIM22
Aliases:
This biomarker is also known as:- E3 ubiquitin-protein ligase TRIM22,
- Tripartite motif-containing protein 22,
- EC 6.3.2.-,
- RNF94,
- TRIM22,
- tripartite motif-containing protein 22,
- staf-50,
- 50 kDa-stimulated trans-acting factor,
- Staf-50,
- stimulated trans-acting factor (50 kDa),
- tripartite motif protein TRIM22,
- tripartite motif-containing 22,
- GPSTAF50,
- tripartite binding motif 22,
- STAF50,
- RING finger protein 94,
- tripartite motif containing 22,
Description…
From NCBI Gene: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Datasets
There are no datasets associated with this biomarker.
Attributes
| QA State: | Curated |
|---|---|
| Type: | Gene |
| HGNC Name: | TRIM22 |
The following organs have data associated with this biomarker…
Attributes
| Phase: | One |
|---|---|
| QA State: | Curated |
Overview
No additional prostate data available.
Performance Comment
Significance Analysis of Microarray (SAM) was used to develop a 7-gene classifier. The overall prediction accuracy and sensitivity is 71% and 76%, respectively. The inclusion of the Gleason sum to the seven-gene classifier raised the prediction accuracy and sensitivity to 83% and 76% respectively This prognostic signature is closely associated with biochemical recurrence in patients after radical prostatectomy. The seven genes are: RRAGD, PQBP1, HIST1H2BC, ALDH1A2, TRIM22, RBPMS, HSPB8.
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
No associated publications found.