Early Detection Research Network


This biomarker is also known as:
  • STAF50,
  • EC 6.3.2.-,
  • Staf-50,
  • tripartite motif protein TRIM22,
  • E3 ubiquitin-protein ligase TRIM22,
  • RING finger protein 94,
  • tripartite motif containing 22,
  • stimulated trans-acting factor (50 kDa),
  • TRIM22,
  • RNF94,
  • tripartite motif-containing protein 22,
  • GPSTAF50,
  • tripartite binding motif 22,
  • tripartite motif-containing 22,
  • 50 kDa-stimulated trans-acting factor,
  • Tripartite motif-containing protein 22,
  • staf-50,


From NCBI Gene: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]


There are no datasets associated with this biomarker.

QA State: Curated
Type: Gene

The following organs have data associated with this biomarker…


Phase: One
QA State: Curated


No additional prostate data available.

Performance Comment

Significance Analysis of Microarray (SAM) was used to develop a 7-gene classifier. The overall prediction accuracy and sensitivity is 71% and 76%, respectively. The inclusion of the Gleason sum to the seven-gene classifier raised the prediction accuracy and sensitivity to 83% and 76% respectively This prognostic signature is closely associated with biochemical recurrence in patients after radical prostatectomy. The seven genes are: RRAGD, PQBP1, HIST1H2BC, ALDH1A2, TRIM22, RBPMS, HSPB8.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.