Early Detection Research Network

TSPO

Aliases:
This biomarker is also known as:
  • DBI,
  • translocator protein,
  • mDRC,
  • Mitochondrial benzodiazepine receptor,
  • BPBS,
  • PKBS,
  • TSPO,
  • MBR,
  • PBS,
  • mitochondrial benzodiazepine receptor,
  • peripheral-type benzodiazepine receptor,
  • PBR,
  • IBP,
  • benzodiazepine peripheral binding site,
  • PBRS,
  • pk18,
  • translocator protein (18kDa),
  • Peripheral-type benzodiazepine receptor,
  • BZRP,
  • PTBR,
  • benzodiazapine receptor (peripheral),

Description…

TSPO is a conserved protein found at the outer mitochondrial membrane. TSPO interacts with some benzodiazepines and isoquinoline carboxamides and has different affinities than its endogenous counterpart. TSPO is also involved in the transport of porphyrins and heme.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: TSPO

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

The TSPO gene is known to be over-expressed in highly aggressive tumors, especially those of the breast. Increasing levels of the TSPO protein are correlated with more advanced stages of breast cancer. Higher TSPO levels are found in estrogen receptor (ER)-negative breast tumors, compared with ER-positive tumors.

Performance Comment

TSPO was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.