Early Detection Research Network

UCHL1

Aliases:
This biomarker is also known as:
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase),
  • UCHL1,
  • UCH-L1,
  • Neuron cytoplasmic protein 9.5,
  • PARK5,
  • Uch-L1,
  • Ubiquitin thioesterase L1,
  • PGP9.5,
  • ubiquitin C-terminal hydrolase,
  • PGP95,
  • ubiquitin carboxyl-terminal hydrolase isozyme L1,
  • PGP 9.5,

Description…

PGP9.5, also called Ubiquitin-protein hydrolase (UCHL1), is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. PGP9.5 has been proposed as a marker with a potential role in carcinogenesis.

Attributes
QA State: Accepted
Type: Protein
HGNC Name: UCHL1

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.