Early Detection Research Network

Colon

Vimentin has no known role in colon cancer, and the VIM gene is not even active in the normal colon. Increased DNA methylation is an epigenetic alteration that is common in human cancers and is often associated with transcriptional silencing. The vimentin gene is transcriptionally silent in normal epithelium. Studies shows that aberrant methylation of exon-1 sequences within the nontranscribed vimentin gene is a novel molecular biomarker of colon cancer and can be successfully detected in fecal DNA to identify nearly half of individuals with colon cancer.
http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/107/125
Curated
Three
Vimentin is in the process of validation and sensitivity/specificity testing in a CLIA/CAP laboratory.
ee28aa99b5d94fa1b5b4ba0fbb401f20
yes
no
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