Early Detection Research Network


This biomarker is also known as:
  • Kidney and brain protein,
  • WW, C2 and coiled-coil domain containing 1,
  • HBEBP3,
  • protein WWC1,
  • KIBRA,
  • WW and C2 domain containing 1,
  • Q8IX03,
  • WW domain-containing protein 1,
  • protein KIBRA,
  • KIAA0869,
  • kidney and brain protein,
  • WWC1,
  • HBEBP36,
  • HBeAg-binding protein 3,


WWC1, or KIBRA, is a cytoplasmic phosphoprotein. Expression has been detected in the brain, heart, colon and kidney, as well as mammary epithelial cells and breast cancer cell lines. WWC1 interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that may be associated with memory performance. Three transcript variants encoding different isoforms have been found for the WWC1 gene.


There are no datasets associated with this biomarker.

QA State: Curated
Type: Protein

The following organs have data associated with this biomarker…


Phase: One
QA State: Under Review


No additional ovarian data available.

Performance Comment

WWC1 (KIBRA) was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. WWC1 (KIBRA) was not in the group of 13 selected for further validation.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.