Early Detection Research Network

XBP1

Aliases:
This biomarker is also known as:
  • XBP-1,
  • TREB5,
  • Tax-responsive element-binding protein 5,
  • XBP2,
  • tax-responsive element-binding protein 5,
  • XBP1,
  • X-box binding protein 1,
  • X-box-binding protein 1,

Description…

XBP1 is a transcription factor involved in hepatocyte growth, differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 regulates MHC class II genes by binding to a promoter element referred to as an X box. XBP1 also plays a role in activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE) during endoplasmic reticulum stress. There is an XBP1 pseudogene on chromosome 5.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: XBP1

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Under Review

Overview

XBP1 is also an estrogen-regulated gene and strongly correlates with estrogen receptor alpha (ERα) expression in breast cancers.

Performance Comment

XBP1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.