Early Detection Research Network

XRCC5

Aliases:
This biomarker is also known as:
  • Ku86 Autoantigen Related Protein 1,
  • TLAA,
  • NFIV,
  • EC 3.6.4.-,
  • X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 5 (Double-Strand-Break Rejoining; Ku Autoantigen, 80kD),
  • DNA Repair Protein XRCC5,
  • X-Ray Repair Cross-Complementing Protein 5,
  • 86 KDa Subunit Of Ku Antigen,
  • ATP-Dependent DNA Helicase 2 Subunit 2,
  • Ku86,
  • Ku Autoantigen, 80kDa,
  • KUB2,
  • KARP-1,
  • CTCBF,
  • Thyroid-Lupus Autoantigen,
  • 80kDa,
  • XRCC5,
  • G22P2,
  • KARP1,
  • X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 5 (Double-Strand-Break Rejoining),
  • KU80,
  • CTC Box-Binding Factor 85 KDa Subunit,
  • ATP-Dependent DNA Helicase II 80 KDa Subunit,
  • Lupus Ku Autoantigen Protein P86,
  • Ku80,
  • Nuclear Factor IV,
  • CTC85,
  • Ku Autoantigen,

Description…

From NCBI Entrez Gene: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
Type: Protein
HGNC Name: XRCC5

The following organs have data associated with this biomarker…

Attributes

Phase: One
QA State: Curated

Overview

XRCC5 is a DNA repair gene overexpressed in some lung cancers. (Zhong et al., J Thorac Oncol. 2006 Jul;1(6):513-9)

Performance Comment

Measurements of the five most predictive antibody markers in 46 cases and controls were combined in a logistic regression model that yielded area under the receiver operating characteristics curve of 0.99; leave-one-out validation achieved 91.3% sensitivity and 91.3% specificity. (Zhong et al., J Thorac Oncol. 2006 Jul;1(6):513-9) The five antibody markers are PXN, EXOC6B (known as SEC15L2 in the publication), BAC clone RP11-499F19, XRCC5, and MALAT1.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

No associated publications found.