Early Detection Research Network

YWHAQ

Aliases:
This biomarker is also known as:
  • 14-3-3 protein tau,
  • YWHAQ,
  • 14-3-3 theta,
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide,
  • Protein HS1,
  • 1C5,
  • 14-3-3 protein theta,
  • protein tau,
  • 14-3-3 protein T-cell,

Description…

YWHAQ, also known as 14-3-3 theta, belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. The 14-3-3 proteins have a wide range of ligands, are involved in a variety of biological pathways, and are known to be overexpressed in some human lung cancers, suggesting that they may play a role in tumorigenesis. 14-3-3 theta is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. It binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. 14-3-3 theta antigens have been found to be targets of autoantibodies in subjects newly diagnosed with lung cancer.

Attributes
QA State: Accepted
Type: Protein
HGNC Name: YWHAQ

The following organs have data associated with this biomarker…

Attributes

Phase: Three
QA State: Under Review
Organ-specific information for this biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact the Informatics Center if you should have access to this biomarker.