Early Detection Research Network

Zhong 5-antibody panel for Lung Cancer

Aliases:
This biomarker is also known as:
  • Zhong 5-antibody panel for Lung Cancer,

Description…

A potential autoantibody profile was developed to screen for non-small cell lung cancer. 212 immunogenic phage-expressed proteins were statistically ranked for their individual reactivity with 23 stage I cancer patient and 23 risk-matched control samples. Measurements of the five most predictive antibody markers in 46 cases and controls were combined. While the identity of these phage-expressed proteins is not critical for use in a diagnostic assay, the identities were determined through a nucleotide search of GenBank. Markers are: paxillin, SEC 15L2, BAC clone RP11-499F19, XRCC5, and MALAT1.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
HGNC Name:

Panel Details

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated

Overview

Antibody profiling may be a useful tool for early detection of NSCLC.

Performance Comment

Measurements of the five most predictive antibody markers in 46 cases and controls were combined in a logistic regression model that yielded area under the receiver operating characteristics curve of 0.99; leave-one-out validation achieved 91.3% sensitivity and 91.3% specificity. (Zhong et al., J Thorac Oncol. 2006 Jul;1(6):513-9)

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