Early Detection Research Network

Zhong TAA signature

Aliases:
This biomarker is also known as:
  • Zhong TAA signature,

Description…

The TAA signature is a diagnostic array of five markers capable of distinguishing patients with non-small cell lung cancer (NSCLC) from normal control subjects. The diagnostic array was developed by enriching and screening phage-expressed tumor-associated proteins, and using these in a fluorescent protein microarray to identify and measure multiple non-small cell lung cancer-associated antibodies and show how simultaneous measurements can be combined into a single diagnostic assay. Although the identity of the phage-expressed proteins is not critical for use in a diagnostic assay, the sequences were compared with the GenBank database to obtain possible identity. The five proteins in the final diagnostic array are GAGE7, BAC clone RP11-499F19, SEC15L2, PMS2P7 (PMS2L15), and EEF1A.

Datasets

There are no datasets associated with this biomarker.

Attributes
QA State: Curated
HGNC Name:

Panel Details

The following organs have data associated with this biomarker…

Attributes

Phase: Two
QA State: Curated

Overview

The data indicates that antibody profiling is a promising approach that could achieve high diagnostic accuracy for non-small cell lung cancer.

Performance Comment

Measurements of the 5 most predictive phage proteins were combined in a logistic regression model that achieved 90% sensitivity and 95% specificity in prediction of patient samples, whereas leave-one-out statistical analysis achieved 88.9% diagnostic accuracy among all 81 samples. (Zhong et. al. Am J Respir Crit Care Med. 2005 Nov 15;172(10):1308-14. Epub 2005 Aug 18) The five proteins are GAGE7, BAC clone RP11-499F19, SEC15L2, PMS2L15, and EEF1A.

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