Early Detection Research Network

Moffitt Imaging Biomarker Validation Center

MIBVC-Heine 2016
449

No coordinating investigator defined.

Several measures of breast density will be evaluated
No design specified.
Other, Specify
Breast and Gynecologic Cancers Research Group

Establish DBT image datasets as a common resource and conduct validation studies.

1a) Establish case/control data sets as EDRN resources. We will first make available our established case-control datasets with images from full field digital mammography (FFDM) with calibration data to EDRN partners. We will continuously establish a case-control dataset with digital breast tomosynthesis (DBT) images including the relevant patient data required for accurate risk assessments and validation as a common resource for EDRN members and external collaborators. We will establish a breast cancer screening consortium for prospective data collection and sharing with established collaborations to enhance this resource. 1b) Conduct validation studies of breast image biomarkers. We will conduct validation studies with 1) DBT images using risk biomarkers (variation, Fourier, and texture metrics) developed and validated previously at Moffitt using conventional mammographic images; and 2) image-derived biomarkers for EDRN partners and external collaborators for breast cancer. Case Inclusion: females (18 or older) with unilateral breast cancer with no prior history of breast cancer and images must be before treatment Case Exclusion: bilateral breast cancer patients, or patients with a history of breast cancer and/or treatment before mammogram Control Inclusion: females (18 and older) with no prior breast cancer and must be an internal (Moffitt) patient Control Exclusion: history of breast cancer or external (non-Moffitt) patient.
Advanced image processing

There are currently no biomarkers annotated for this protocol.

No datasets are currently associated with this protocol.