Early Detection Research Network

Assignment of retinoblastoma susceptibility gene to mouse chromosome 14.

A human cDNA probe was used to screen a panel of mouse-Chinese hamster somatic cell hybrids to determine the chromosomal location of the retinoblastoma susceptibility gene (Rb-1) in mouse. The Rb-1 gene mapped to mouse chromosome 14. Thus, the retinoblastoma susceptibility gene is syntenic with esterase 10 (the mouse homolog of human esterase D). The chromosomal assignment of the mouse Rb-1 gene was further confirmed by using the same probe to study mouse-rat microcell hybrids. Since the human retinoblastoma susceptibility gene (RB1) along with the gene for esterase D is on chromosome 13q14, these data indicate this linkage group is conserved in man and mouse.

Hsieh CL, Killary AM, Lalley PA, Lee EY, Lee WH, Naylor SL

2781416

Somat. Cell Mol. Genet., 1989, 15 (5)