Early Detection Research Network

Bruce, Margaret

Contact Information

Email: mailto:mvbruce@mdanderson.org
Fax:
3184
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To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

None Available.

Closed Protocols

No closed protocols.

Publications

Publication Name PubMed ID Journal
2-D or not 2-D--is there a future for 2-D gels in proteomics? Insights from the York proteomics meeting. 11678032 Proteomics
A database of protein expression in lung cancer. 11721642 Proteomics
A distinct repertoire of autoantibodies in hepatocellular carcinoma identified by proteomic analysis. 12096119 Mol. Cell Proteomics
A functional annotation of subproteomes in human plasma. 16104058 Proteomics
A meeting of minds in proteomics. 11822353 Proteomics
A minimal critical region of the 8p22-23 amplicon in esophageal adenocarcinomas defined using sequence tagged site-amplification mapping and quantitative polymerase chain reaction includes the GATA-4 gene. 10728696 Cancer Res.
A mouse plasma peptide atlas as a resource for disease proteomics. 18522751 Genome Biol.
A mouse to human search for plasma proteome changes associated with pancreatic tumor development. 18547137 PLoS Med.
A proteomic approach to the identification of lung cancer markers. 11790896 Dis. Markers
A proteomics platform combining depletion, multi-lectin affinity chromatography (M-LAC), and isoelectric focusing to study the breast cancer proteome. 21513341 Anal. Chem.
A wide range of protein isoforms in serum and plasma uncovered by a quantitative intact protein analysis system. 16047307 Proteomics
Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework. 14578198 Am. J. Pathol.
An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer. 11504947 Proc. Natl. Acad. Sci. U.S.A.
Application of proteomics to cancer early detection. 22157286 Cancer J
Biomedical applications of two-dimensional electrophoresis using immobilized pH gradients: current status. 10786892 Electrophoresis
Challenges in deriving high-confidence protein identifications from data gathered by a HUPO plasma proteome collaborative study. 16525410 Nat. Biotechnol.
Cleavage of endoplasmic reticulum proteins in hepatocellular carcinoma: Detection of generated fragments in patient sera. 16762624 Gastroenterology
Comprehensive proteomic profiling of aldehyde dehydrogenases in lung adenocarcinoma cell lines. 22110949 Int J Proteomics
Computational Proteomics Analysis System (CPAS): an extensible, open-source analytic system for evaluating and publishing proteomic data and high throughput biological experiments. 16396501 J. Proteome Res.
Concordant release of glycolysis proteins into the plasma preceding a diagnosis of ER+ breast cancer. 22367215 Cancer Res.
Confounding effects of hormone replacement therapy in protein biomarker studies. 21037107 Cancer Epidemiol. Biomarkers Prev.
Contribution of protein fractionation to depth of analysis of the serum and plasma proteomes. 17696519 J. Proteome Res.
Contributions of proteome profiling to the molecular analysis of cancer. 12625782 Technol. Cancer Res. Treat.
Discordant protein and mRNA expression in lung adenocarcinomas. 12096112 Mol. Cell Proteomics
Discovery of cancer biomarkers through the use of mouse models. 17320282 Cancer Lett.
Discovery of cancer biomarkers through the use of mouse models. 17320282 Cancer Lett.
Disease proteomics. 12634796 Nature
Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis. 16117833 BMC Cancer
Emerging molecular biomarkers--blood-based strategies to detect and monitor cancer. 21364687 Nat Rev Clin Oncol
Evaluation of known oncoantibodies, HER2, p53, and cyclin B1, in prediagnostic breast cancer sera. 22715141 Cancer Prev Res (Phila)
Expression of matrix metalloproteinase 9 (MMP-9/gelatinase B) in adenocarcinomas strongly correlated with expression of immune response genes. 12954092 In Silico Biol. (Gedrukt)
Gene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas. 12681502 FEBS Lett.
Gene-expression profiles predict survival of patients with lung adenocarcinoma. 12118244 Nat. Med.
Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics. 11943782 J. Biol. Chem.
Global profiling of gene expression in cancer using genomics and proteomics. 11804268 Curr. Opin. Mol. Ther.
Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. 12493773 J. Biol. Chem.
Harnessing immunity for cancer marker discovery. 12511908 Nat. Biotechnol.
Harnessing the immune response for cancer detection. 21454417 Cancer Epidemiol. Biomarkers Prev.
High-throughput genomic technology in research and clinical management of breast cancer. Plasma-based proteomics in early detection and therapy. 17184556 Breast Cancer Res.
Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer. 18089831 Cancer Res.
Identification of a Specific Vimentin Isoform That Induces an Antibody Response in Pancreatic Cancer. 18769604 Biomark Insights
Identification of androgen-regulated genes in the prostate cancer cell line LNCaP by serial analysis of gene expression and proteomic analysis. 11721644 Proteomics
Identification of beta-tubulin isoforms as tumor antigens in neuroblastoma. 11051243 Clin. Cancer Res.
Identification of tumor-associated antigens using proteomics. 12625784 Technol. Cancer Res. Treat.
Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas. 12970743 Oncogene
Increased throughput and reduced carryover of mass spectrometry-based proteomics using a high-efficiency nonsplit nanoflow parallel dual-column capillary HPLC system. 18512973 J. Proteome Res.
Innovative proteomic approaches for cancer biomarker discovery. 17907570 BioTechniques
Intact-protein analysis system for discovery of serum-based disease biomarkers. 21468941 Methods Mol. Biol.
Integral protein microarrays for the identification of lung cancer antigens in sera that induce a humoral immune response. 17916591 Mol. Cell Proteomics
Integrated mass spectrometry-based analysis of plasma glycoproteins and their glycan modifications. 21372808 Nat Protoc
Integrating cancer genomics and proteomics in the post-genome era. 11788993 Proteomics
Integration of proteomics into systems biology of cancer. 22407608 Wiley Interdiscip Rev Syst Biol Med
Isoelectric focusing nonporous RP HPLC: a two-dimensional liquid-phase separation method for mapping of cellular proteins with identification using MALDI-TOF mass spectrometry. 10740846 Anal. Chem.
Isoform analysis of LC-MS/MS data from multidimensional fractionation of the serum proteome. 18419151 J. Proteome Res.
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. 21907921 Cancer Cell
Making sense of microarray data to classify cancer. 14597962 Pharmacogenomics J.
Microarrays of tumor cell derived proteins uncover a distinct pattern of prostate cancer serum immunoreactivity. 14595819 Proteomics
Microparticles from ovarian carcinomas are shed into ascites and promote cell migration. 22315094 Int. J. Gynecol. Cancer
Mining gene expression databases for association rules. 12499296 Bioinformatics
Mining the plasma proteome for disease applications across seven logs of protein abundance. 21062094 J. Proteome Res.
Mining the plasma proteome for cancer biomarkers. 18385731 Nature
Molecular analysis of cancer using DNA and protein microarrays. 12908549 Adv. Exp. Med. Biol.
Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. 12750293 Cancer Res.
Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3. 14595809 Proteomics
Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. 17418409 Cancer Cell
Multi-dimensional liquid phase based separations in proteomics. 12659729 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Operomics: integrated genomic and proteomic profiling of cells and tissues. 15251063 Brief Funct Genomic Proteomic
Operomics: molecular analysis of tissues from DNA to RNA to protein. 11097332 Clin. Chem. Lab. Med.
Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas. 12644570 Mol. Cell Proteomics
Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. 16104056 Proteomics
Plasma proteome profiles associated with inflammation, angiogenesis, and cancer. 21589862 PLoS ONE
Plasma proteome profiling of a mouse model of breast cancer identifies a set of up-regulated proteins in common with human breast cancer cells. 18311905 J. Proteome Res.
Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice. 12844362 Genome Biol.
Profiling of the cell surface proteome. 14625857 Proteomics
Protein based microarrays: a tool for probing the proteome of cancer cells and tissues. 11721639 Proteomics
Protein profiles associated with survival in lung adenocarcinoma. 14573703 Proc. Natl. Acad. Sci. U.S.A.
Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma. 12192603 Neoplasia
Proteomic analysis of eIF-5A in lung adenocarcinomas. 12687616 Proteomics
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors. 12114434 Clin. Cancer Res.
Proteomic approaches for cancer biomarker discovery in plasma. 17941811 Expert Rev Proteomics
Proteomic approaches within the NCI early detection research network for the discovery and identification of cancer biomarkers. 11708463 Ann. N. Y. Acad. Sci.
Proteomics approaches to uncover the repertoire of circulating biomarkers for breast cancer. 12882525 J Mammary Gland Biol Neoplasia
Proteomics in early detection of cancer. 11568117 Clin. Chem.
Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer. 11691811 Cancer Res.
Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. 11705844 Clin. Cancer Res.
Quantitative analysis of acrylamide labeled serum proteins by LC-MS/MS. 16889424 J. Proteome Res.
RANTES expression is a predictor of survival in stage I lung adenocarcinoma. 12473593 Clin. Cancer Res.
Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer. 21987723 Cancer Res.
The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas. 11280781 Cancer Res.
The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas. 12234996 Cancer Res.
The Human Proteome Organization: a mission to advance proteome knowledge. 12169681 Mol. Cell Proteomics
The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. 11278880 J. Biol. Chem.
Transforming properties of a Q18-->E mutation of the microtubule regulator Op18. 12242154 Cancer Cell
Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression. 21653680 Cancer Res.
Two messenger RNAs and five isoforms for Po66-CBP, a galectin-8 homolog in a human lung carcinoma cell line. 11675018 Gene
Ubiquitin COOH-terminal hydrolase 1: a biomarker of renal cell carcinoma associated with enhanced tumor cell proliferation and migration. 17200335 Clin. Cancer Res.
Ubiquitin COOH-terminal hydrolase 1: a biomarker of renal cell carcinoma associated with enhanced tumor cell proliferation and migration. 17200335 Clin. Cancer Res.
Unraveling the complex proteome for biomarker discovery in gastrointestinal and liver diseases. 17064703 Gastroenterology
Virtual genome scan: a tool for restriction landmark-based scanning of the human genome. 11483587 Genome Res.

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.