Early Detection Research Network

Willette, Bill

Contact Information

Email: mailto:bwillett@fredhutch.org
Fax:
3482
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Open Protocols

None Available.

Closed Protocols

No closed protocols.

Publications

Publication Name PubMed ID Journal
[-2]proenzyme prostate specific antigen for prostate cancer detection: a national cancer institute early detection research network validation study. 18550118 J. Urol.
A <i>K</i>-fold Averaging Cross-validation Procedure. 27630515 J Nonparametr Stat
A model for the design and construction of a resource for the validation of prognostic prostate cancer biomarkers: the Canary Prostate Cancer Tissue Microarray. 23232570 Adv Anat Pathol
A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus. 19435894 Cancer Res.
A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. 18316555 Clin. Cancer Res.
A new family-based association test via a least-squares method. 16451567 BMC Genet.
A parametric ROC model-based approach for evaluating the predictiveness of continuous markers in case-control studies. 19459841 Biometrics
A practical multifaceted approach to selecting differentially expressed genes. 19455259 Cancer Inform
A prospective, multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness. 20447916 Cancer Epidemiol. Biomarkers Prev.
A regularized multivariate regression approach for eQTL analysis. 26085849 Stat Biosci
A sparse Ising model with covariates. 25099186 Biometrics
A statistical method for detecting differentially expressed SNVs based on next-generation RNA-seq data. 27276420 Biometrics
A web-based system for managing and co-ordinating multiple multisite studies. 16279578 Clin Trials
Accommodating Covariates in ROC Analysis. 20046933 Stata J
Activated leukocyte cell adhesion molecule: a novel biomarker for breast cancer. 19322904 Int. J. Cancer
Adjusting for covariate effects on classification accuracy using the covariate-adjusted receiver operating characteristic curve. 22822245 Biometrika
Adjusting for covariates in studies of diagnostic, screening, or prognostic markers: an old concept in a new setting. 18477651 Am. J. Epidemiol.
Adopting nested case-control quota sampling designs for the evaluation of risk markers. 23807695 Lifetime Data Anal
Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma. 19362088 Gastroenterology
An Automated Peak Identification/Calibration Procedure for High-Dimensional Protein Measures From Mass Spectrometers. 14615632 J. Biomed. Biotechnol.
Analysis of serum haptoglobin fucosylation in hepatocellular carcinoma and liver cirrhosis of different etiologies. 24807840 J. Proteome Res.
Analyzing LC-MS/MS data by spectral count and ion abundance: two case studies. 24163717 Stat Interface
Application of Multidimensional Selective Item Response Regression Model for Studying Multiple Gene Methylation in SV40 Oncogenic Pathways. 19830254 J Am Stat Assoc
Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers. 16542256 Biometrics
Aspects of the design and analysis of high-dimensional SNP studies for disease risk estimation. 16443924 Biostatistics
Assessing accuracy of mammography in the presence of verification bias and intrareader correlation. 15737102 Biometrics
Assessing risk prediction models in case-control studies using semiparametric and nonparametric methods. 20527013 Stat Med
Assessing the diagnostic accuracy of a sequence of tests. 12925502 Biostatistics
Assessing the value of risk predictions by using risk stratification tables. 19017593 Ann. Intern. Med.
Assessing treatment-selection markers using a potential outcomes framework. 22299708 Biometrics
Association Between Combined TMPRSS2:ERG and PCA3 RNA Urinary Testing and Detection of Aggressive Prostate Cancer. 28520829 JAMA Oncol
Association of HPC2/ELAC2 polymorphisms with risk of prostate cancer in a population-based study. 14504198 Cancer Epidemiol. Biomarkers Prev.
Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers. 19255861 Cancer Causes Control
Asymptotic Properties of the Sequential Empirical ROC, PPV and NPV Curves Under Case-Control Sampling. 24039313 Ann Stat
Bias-reduced estimators and confidence intervals for odds ratios in genome-wide association studies. 18310059 Biostatistics
Biases introduced by choosing controls to match risk factors of cases in biomarker research. 22730452 Clin. Chem.
Biomarker evaluation and comparison using the controls as a reference population. 18755739 Biostatistics
Boosted decision tree analysis of surface-enhanced laser desorption/ionization mass spectral serum profiles discriminates prostate cancer from noncancer patients. 12324514 Clin. Chem.
Boosting with missing predictors. 19948743 Biostatistics
BOOTSTRAP INFERENCE FOR NETWORK CONSTRUCTION WITH AN APPLICATION TO A BREAST CANCER MICROARRAY STUDY. 24563684 Ann Appl Stat
Borrowing Information across Populations in Estimating Positive and Negative Predictive Values. 22021938 J R Stat Soc Ser C Appl Stat
Can urinary PCA3 supplement PSA in the early detection of prostate cancer? 25385735 J. Clin. Oncol.
Canary Prostate Active Surveillance Study: design of a multi-institutional active surveillance cohort and biorepository. 19758683 Urology
Characterizing expected benefits of biomarkers in treatment selection. 25190512 Biostatistics
Classification versus association models: should the same methods apply? 20515278 Scand. J. Clin. Lab. Invest. Suppl.
Clinical utility of five genetic variants for predicting prostate cancer risk and mortality. 19058137 Prostate
Combining biomarkers linearly and nonlinearly for classification using the area under the ROC curve. 27058981 Stat Med
Combining biomarkers to detect disease with application to prostate cancer. 14557109 Biostatistics
Combining predictors for classification using the area under the receiver operating characteristic curve. 16542249 Biometrics
Combining results of microarray experiments: a rank aggregation approach. 17049026 Stat Appl Genet Mol Biol
Combining several screening tests: optimality of the risk score. 12230001 Biometrics
Commentary: Reporting standards are needed for evaluations of risk reclassification. 21571811 Int J Epidemiol
Comments on 'Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond' by M. J. Pencina et al., Statistics in Medicine (DOI: 10.1002/sim.2929). 17671958 Stat Med
Comparing the predictive values of diagnostic tests: sample size and analysis for paired study designs. 16895044 Clin Trials
Comparison of two correlated ROC curves at a given specificity or sensitivity level. 27324068 Stat Med
Conditional estimation after a two-stage diagnostic biomarker study that allows early termination for futility. 22238117 Stat Med
Conditional estimation of sensitivity and specificity from a phase 2 biomarker study allowing early termination for futility. 19097251 Stat Med
Construction and analysis of the NCI-EDRN breast cancer reference set for circulating markers of disease. 25471344 Cancer Epidemiol. Biomarkers Prev.
Contrasting two frameworks for ROC analysis of ordinal ratings. 20147599 Med Decis Making
Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner. 21272319 Nutr J
Design and estimation for evaluating principal surrogate markers in vaccine trials. 23409839 Biometrics
Detecting genomic aberrations using products in a multiscale analysis. 19817738 Biometrics
Development of common data elements: the experience of and recommendations from the early detection research network. 12706181 Int J Med Inform
Diagnostic markers for early detection of ovarian cancer. 18258665 Clin. Cancer Res.
Distribution-free ROC analysis using binary regression techniques. 12933607 Biostatistics
Does the net reclassification improvement help us evaluate models and markers? 24592500 Ann. Intern. Med.
Early-Phase Studies of Biomarkers: What Target Sensitivity and Specificity Values Might Confer Clinical Utility? 27001493 Clin. Chem.
Efficient use of longitudinal CD4 counts and viral load measures in survival analysis. 22415871 Stat Med
Epidemiology informing clinical practice: from bills of mortality to population laboratories. 16341118 Nat Clin Pract Oncol
Estimating improvement in prediction with matched case-control designs. 23358916 Lifetime Data Anal
Estimating Risk with Time-to-Event Data: An Application to the Women's Health Initiative. 25018574 J Am Stat Assoc
Estimating the capacity for improvement in risk prediction with a marker. 18714084 Biostatistics
Estimating the diagnostic likelihood ratio of a continuous marker. 20639522 Biostatistics
Estimating the receiver operating characteristic curve in studies that match controls to cases on covariates. 23601953 Acad Radiol
Estimation and Comparison of Receiver Operating Characteristic Curves. 20161343 Stata J
Evaluating and comparing biomarkers with respect to the area under the receiver operating characteristics curve in two-phase case-control studies. 26883772 Biostatistics
Evaluating incremental values from new predictors with net reclassification improvement in survival analysis. 23254468 Lifetime Data Anal
Evaluating markers for selecting a patient's treatment. 15606407 Biometrics
Evaluating prognostic accuracy of biomarkers in nested case-control studies. 21856652 Biostatistics
Evaluating prognostic accuracy of biomarkers under competing risk. 22150576 Biometrics
Evaluating technologies for classification and prediction in medicine. 16320261 Stat Med
Evaluating the predictive value of biomarkers with stratified case-cohort design. 23173848 Biometrics
Evaluating the predictiveness of a continuous marker. 17489968 Biometrics
Evaluating the ROC performance of markers for future events. 18064569 Lifetime Data Anal
Evaluation of matrix-assisted laser desorption/ionization-time of flight mass spectrometry proteomic profiling: identification of alpha 2-HS glycoprotein B-chain as a biomarker of diet. 15841498 Proteomics
Extended lifespan of Barrett's esophagus epithelium transduced with the human telomerase catalytic subunit: a useful in vitro model. 12807723 Carcinogenesis
FDR-controlling testing procedures and sample size determination for microarrays. 15977294 Stat Med
Further insight into the incremental value of new markers: the interpretation of performance measures and the importance of clinical context. 22875756 Am. J. Epidemiol.
Gauging the performance of SNPs, biomarkers, and clinical factors for predicting risk of breast cancer. 18612128 J. Natl. Cancer Inst.
Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China. 19064562 Cancer Epidemiol. Biomarkers Prev.
Genomic instability and copy-number heterogeneity of chromosome 19q, including the kallikrein locus, in ovarian carcinomas. 20800559 Mol Oncol
Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women. 17624589 Breast Cancer Res. Treat.
Glycosylation variants of mucins and CEACAMs as candidate biomarkers for the diagnosis of pancreatic cystic neoplasms. 20395854 Ann. Surg.
Group sequential testing of the predictive accuracy of a continuous biomarker with unknown prevalence. 26537180 Stat Med
Identification of osteopontin as a novel marker for early hepatocellular carcinoma. 21953299 Hepatology
Identifying optimal biomarker combinations for treatment selection via a robust kernel method. 25124089 Biometrics
Identifying target populations for screening or not screening using logic regression. 15568185 Stat Med
Immunohistochemical validation of expression microarray results. 15858137 J Mol Diagn
Improved Detection of Hepatocellular Carcinoma by Using a Longitudinal Alpha-Fetoprotein Screening Algorithm. 26260109 Clin. Gastroenterol. Hepatol.
Improving biomarker identification with better designs and reporting. 21666069 Clin. Chem.
IMPROVING EFFICIENCY IN BIOMARKER INCREMENTAL VALUE EVALUATION UNDER TWO-PHASE DESIGNS. 28943991 Ann Appl Stat
Improving risk classification of critical illness with biomarkers: a simulation study. 23566734 J Crit Care
Improving the quality of biomarker discovery research: the right samples and enough of them. 25837819 Cancer Epidemiol. Biomarkers Prev.
Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women. 22277732 Cancer Prev Res (Phila)
Insights into latent class analysis of diagnostic test performance. 17085745 Biostatistics
Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and the risk of fibrocystic breast conditions among Chinese women. 16331609 Int. J. Cancer
Integrated proteomic profiling of cell line conditioned media and pancreatic juice for the identification of pancreatic cancer biomarkers. 21653254 Mol. Cell Proteomics
Joint modeling, covariate adjustment, and interaction: contrasting notions in risk prediction models and risk prediction performance. 21968770 Epidemiology
Letter by Pepe et al regarding article, "Use and misuse of the receiver operating characteristic curve in risk prediction". 17679623 Circulation
Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. 15105181 Am. J. Epidemiol.
LOGISTIC REGRESSION ANALYSIS WITH STANDARDIZED MARKERS. 24204441 Ann Appl Stat
Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability. 22412972 PLoS ONE
Matching in studies of classification accuracy: implications for analysis, efficiency, and assessment of incremental value. 17501939 Biometrics
Measures to summarize and compare the predictive capacity of markers. 20224632 Int J Biostat
Measuring the performance of markers for guiding treatment decisions. 21320940 Ann. Intern. Med.
Methods for Assessing Improvement in Specificity when a Biomarker is Combined with a Standard Screening Test. 20054437 Stat Biopharm Res
Model checking for ROC regression analysis. 17447940 Biometrics
Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk. 18483343 Cancer Epidemiol. Biomarkers Prev.
Net risk reclassification p values: valid or misleading? 24681599 J. Natl. Cancer Inst.
New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization. 24124229 Cancer Discov
Nidogen-2: a new serum biomarker for ovarian cancer. 19883638 Clin. Biochem.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera. 18794547 J. Clin. Oncol.
On longitudinal prediction with time-to-event outcome: Comparison of modeling options. 27438160 Biometrics
Optimized normalization for antibody microarrays and application to serum-protein profiling. 15793073 Mol. Cell Proteomics
Partial AUC estimation and regression. 14601762 Biometrics
Partially supervised learning using an EM-boosting algorithm. 15032790 Biometrics
Partly conditional survival models for longitudinal data. 16011684 Biometrics
Performance of a single assay for both type III and type VI TMPRSS2:ERG fusions in noninvasive prediction of prostate biopsy outcome. 18948370 Clin. Chem.
Personalized Evaluation of Biomarker Value: A Cost-Benefit Perspective. 27446505 Stat Biosci
Phases of biomarker development for early detection of cancer. 11459866 J. Natl. Cancer Inst.
Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: standards for study design. 18840817 J. Natl. Cancer Inst.
Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms. 26549697 Sci Rep
Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women. 18483327 Cancer Epidemiol. Biomarkers Prev.
Polymorphisms in the glutathione S-transferase M1, T1, and P1 genes and prostate cancer prognosis. 16921513 Prostate
Predicting time to prostate cancer recurrence based on joint models for non-linear longitudinal biomarkers and event time outcomes. 12483774 Stat Med
Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel. 18766180 Br. J. Cancer
Prediction of patient-specific risk and percentile cohort risk of pathological stage outcome using continuous prostate-specific antigen measurement, clinical stage and biopsy Gleason score. 20875091 BJU Int.
Presence of simian virus 40 DNA sequences in human lymphomas. 11897287 Lancet
Prevalidation of salivary biomarkers for oral cancer detection. 22301830 Cancer Epidemiol. Biomarkers Prev.
Pro-surfactant protein B as a biomarker for lung cancer prediction. 24248694 J. Clin. Oncol.
Problems with risk reclassification methods for evaluating prediction models. 21555714 Am. J. Epidemiol.
Prospective accuracy for longitudinal markers. 17688486 Biometrics
Prostate cancer specific mortality and Gleason 7 disease differences in prostate cancer outcomes between cases with Gleason 4 + 3 and Gleason 3 + 4 tumors in a population based cohort. 19836772 J. Urol.
Quantifying and comparing the predictive accuracy of continuous prognostic factors for binary outcomes. 14744831 Biostatistics
Quantifying and comparing the accuracy of binary biomarkers when predicting a failure time outcome. 15122736 Stat Med
Quantifying peptide signal in MALDI-TOF mass spectrometry data. 16195224 Mol. Cell Proteomics
Re: "Clinical usefulness of the Framingham cardiovascular risk profile beyond its statistical performance: the Tehran Lipid and Glucose Study". 23524037 Am. J. Epidemiol.
Reproducible two-dimensional capillary electrophoresis analysis of Barrett's esophagus tissues. 16944874 Anal. Chem.
Resampling Procedures for Making Inference under Nested Case-control Studies. 24436503 J Am Stat Assoc
Response. 25432412 J. Natl. Cancer Inst.
Robust prediction of t-year survival with data from multiple studies. 20670303 Biometrics
Robust risk prediction with biomarkers under two-phase stratified cohort design. 27037494 Biometrics
Sample size calculations for comparative studies of medical tests for detecting presence of disease. 11870820 Stat Med
Scale-based normalization of spectral data. 17192066 Cancer Biomark
Selecting differentially expressed genes from microarray experiments. 12762450 Biometrics
Semiparametric estimation of time-dependent ROC curves for longitudinal marker data. 15475423 Biostatistics
Semiparametric methods for evaluating the covariate-specific predictiveness of continuous markers in matched case-control studies. 21562626 J R Stat Soc Ser C Appl Stat
Semiparametric methods for evaluating risk prediction markers in case-control studies. 22822247 Biometrika
Semiparametric models of time-dependent predictive values of prognostic biomarkers. 19397579 Biometrics
Serum protein fingerprinting coupled with a pattern-matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men. 12097261 Cancer Res.
Standardizing diagnostic markers to evaluate and compare their performance. 16135934 Epidemiology
Statistical Aspects of the Use of Biomarkers in Nutritional Epidemiology Research. 19841649 Stat Biosci
Statistical considerations in combining biomarkers for disease classification. 15322313 Dis. Markers
Statistical issues in the evaluation of screening and early detection modalities. 18452826 Urol. Oncol.
Statistical Methods for Tissue Array Images - Algorithmic Scoring and Co-training. 22984376 Ann Appl Stat
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. 21407270 Eur. J. Hum. Genet.
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. 21434890 Eur. J. Clin. Invest.
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. 21424820 Eur. J. Epidemiol.
Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): explanation and elaboration. 21414753 J Clin Epidemiol
Structured penalties for functional linear models-partially empirical eigenvectors for regression. 22639702 Electron J Stat
Survival model predictive accuracy and ROC curves. 15737082 Biometrics
Telomere length in the colon declines with age: a relation to colorectal cancer? 16537718 Cancer Epidemiol. Biomarkers Prev.
Testing for improvement in prediction model performance. 23296397 Stat Med
The analysis of placement values for evaluating discriminatory measures. 15180681 Biometrics
The Early Detection Research Network's Specimen reference sets: paving the way for rapid evaluation of potential biomarkers. 23193062 Clin. Chem.
The joint graphical lasso for inverse covariance estimation across multiple classes. 24817823 J R Stat Soc Series B Stat Methodol
The optimal ratio of cases to controls for estimating the classification accuracy of a biomarker. 16428259 Biostatistics
The potential of genes and other markers to inform about risk. 20160267 Cancer Epidemiol. Biomarkers Prev.
The risk of biopsy-detectable prostate cancer using the prostate cancer prevention Trial Risk Calculator in a community setting. 22552047 Urol. Oncol.
The sensitivity and specificity of markers for event times. 16079162 Biostatistics
The use of kallikrein-related peptidases as adjuvant prognostic markers in colorectal cancer. 19367279 Br. J. Cancer
Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features. 18382671 PLoS ONE
Time-dependent Predictive Values of Prognostic Biomarkers with Failure Time Outcome. 19655041 J Am Stat Assoc
Two-stage biomarker panel study and estimation allowing early termination for futility. 25964662 Biostatistics
Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. 18519043 Gastroenterology
Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation. 21363920 Cancer Res.
Ultrasensitive detection and characterization of posttranslational modifications using surface-enhanced Raman spectroscopy. 16737206 Anal. Chem.
Unbiased estimation of biomarker panel performance when combining training and testing data in a group sequential design. 26845527 Biometrics
Using the ROC curve for gauging treatment effect in clinical trials. 16220481 Stat Med
Vitamin D receptor gene polymorphisms and prostate cancer risk. 15065089 Prostate
When does combining markers improve classification performance and what are implications for practice? 23348801 Stat Med

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