Bigbee, William L.

Contact Information

Email:	mailto:bigbeewl@upmc.edu
Fax:	412-641-2458

DMCC Person ID: A code assigned by the DMCC to identify this person; may be blank for non-EDRN people.

EDRN Title: EDRN Associate Member

Specialty: None given

To update contact information, please visit the Data Management and Coordinating Center.

Open Protocols

Protocol Name	Biomarkers	Datasets
Collaborative study on SELDI biomarker discovery and serum protein profiling of lung cancers	0	0
EDRN Informatics Pilot Project	0	0

Closed Protocols

Protocol Name	Biomarkers	Datasets
Autoantibody Approach for Serum-Based Detection of Head and Neck Cancer	8	0
EDRN Resource Network Exchange	0	0
EDRN-WHI Pre-Clinical Colon Ca Specimens	0	9
Proteomic Approach for Diagnostic Applications in Head and Neck Cancer	0	0
Proteomic Profiling of Serum and Other Body Fluids for the Early Detection of Colon Cancers	0	0
SELDI Phase I: Assay Validation-Prostate	0	1
SELDI Validation Study Phase II	0	3
Standard Specimen Reference Set: Lung	0	0

Publications

Publication Name	PubMed ID	Journal
[Analysis of proteomic spectra in serum from patients with laryngeal carcinoma by SELDI-TOF-MS technology].	20359086	Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
[Rabies vaccination with regards to its epidemiology (author's transl)].	1237467	Immun. Infekt.
Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer.	16424007	Cancer Res.
Assessing the statistical significance of the achieved classification error of classifiers constructed using serum peptide profiles, and a prescription for random sampling repeated studies for massive high-throughput genomic and proteomic studies.	19305632	Cancer Inform
Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract.	15754315	Mol. Carcinog.
Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract.	15754315	Mol. Carcinog.
Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer.	12844488	Carcinogenesis
Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer.	12844488	Carcinogenesis
Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma.	17409457	Cancer Res.
Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics.	14718398	Clin. Chem.
Colon cancer specific nuclear matrix protein alterations in human colonic adenomatous polyps.	14743395	J. Cell. Biochem.
Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer.	17909350	J Thorac Oncol
Early detection of head and neck cancer: development of a novel screening tool using multiplexed immunobead-based biomarker profiling.	17220337	Cancer Epidemiol. Biomarkers Prev.
Early identification of individuals with prostate cancer in negative biopsies.	15017188	J. Urol.
Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility.	15613711	Clin. Chem.
Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility.	15613711	Clin. Chem.
Feature Selection for Classification of SELDI-TOF-MS Proteomic Profiles.	16309341	Appl. Bioinformatics
Frequent expression of Niban in head and neck squamous cell carcinoma and squamous dysplasia.	19536772	Head Neck
Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck.	11880476	J. Natl. Cancer Inst.
Identification of calreticulin as a nuclear matrix protein associated with human colon cancer.	12704787	J. Cell. Biochem.
Identification of nuclear matrix protein alterations associated with human colon cancer.	11956108	Cancer Res.
Initial analyses of colon cancer-specific antigen (CCSA)-3 and CCSA-4 as colorectal cancer-associated serum markers.	17575123	Cancer Res.
Intersession reproducibility of mass spectrometry profiles and its effect on accuracy of multivariate classification models.	17766268	Bioinformatics
Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor.	13679857	Oncogene
Multianalyte profiling of serum cytokines for detection of pancreatic cancer.	17192050	Cancer Biomark
Multiple cytokine and growth factor serum biomarkers predict therapeutic response and survival in advanced-stage head and neck cancer patients.	17545511	Clin. Cancer Res.
Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients.	15744170	Laryngoscope
No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer.	15066937	Cancer Epidemiol. Biomarkers Prev.
SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer.	18024530	Clin. Chem.
Serum protein expression profiling for cancer detection: validation of a SELDI-based approach for prostate cancer.	15258333	Dis. Markers
SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.	15342401	Cancer Res.

To update protocols, publications, biomarkers, or science data, please contact the Informatics Center.